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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Mar Ago 16, 2011 12:08 pm
Significa que esto es muy buena idea Dr. Fer, no alucine, no es nada malo... es un icono de un foquito encendido Smile
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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Mar Ago 16, 2011 12:17 pm
esque con eso de q volteaste bandera....... ya no se sabe!!! tongue tongue
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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Mar Ago 16, 2011 12:19 pm
Clinical prognostic factors in multiple sclerosis: a natural history review.
Degenhardt A, Ramagopalan SV, Scalfari A, Ebers GC.
Source

Department of Clinical Neurology, University of Oxford, Oxford, UK.
Abstract

This Review summarizes the natural history studies on multiple sclerosis (MS) that have evaluated prognostic factors. Reassessment of prognostic factors is warranted, as our ability to offer patients a reliable prognosis is limited, yet we rely on this knowledge to appropriately design clinical trials and interpret their results. The selection criteria for studies to review included a geographical referral base, duration of at least 9 years, prospective design, and populations of at least 100 patients with MS. For all forms of MS combined, negative prognostic factors included progressive disease, and disability at 2 and 5 years. In relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) combined, negative prognostic factors were the onset of progression, a higher relapse rate, greater disability in the first 5 years, a shorter interval to the second relapse, and the involvement of more systems. Additional negative factors include a shorter time to progression in SPMS and a faster rate of disability in the first 2 and 5 years in primary progressive MS (PPMS). Onset of progression, relapse rate and disability in the initial 5 years could be fruitful therapeutic targets; however, longer-term clinical trials will be required to justify these end points

What do the authors offer in this paper?

a) Adequately select patients for clinical trials
b) Design clinical trials and interpret their results
c) Use a specific inclussion judgement
d) Long follow up



What could be a productive intervention in the first years?

a) Beginning of evolution, relapse rate and disability
b) Monitoring of treatment
c) Reassessment of prognostic factors
d) Control disability


What does 2 and 5 years mean in this part of the paper?

a) Geographical referral
b) Clinical markers
c) Relapsing remitting MS
d) Negative prognostic factors

What iniciated the onset of progression of RRMS and SPMS ?

a) Atrial fibrillation
b) Negative prognostic factors
c) Justification of end points
d) The age of patients




RESP:
1:B
2:A
3:D
4:B

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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Miér Ago 17, 2011 12:04 pm
OBJECTIVE:

Cerebrospinal fluid (CSF) metastasis is the most difficult type of retinoblastoma metastasis to cure, even with bone marrow transplant. Most metastatic retinoblastoma cells express P-glycoprotein causing multidrug resistance (MDR). P-glycoprotein-rich blood vessels form blood-brain and blood-eye barriers, inhibit drug entry into central nervous system (CNS) and eyes. High-dose craniospinal radiation is too morbid for treatment of young children. To cure CSF metastasis without radiation, we designed an intensive multimodality chemotherapy regimen.
METHOD:

After left eye enucleation, a 4-month-old boy with bilateral International Intraocular Retinoblastoma Classification Group E eyes and CSF metastasis was treated with 7-cycle high-dose carboplatin and etoposide, standard-dose vincristine, and high-dose/short-infusion cyclosporine to inhibit P-glycoprotein. Intraventricular drugs, non-substrate of P-glycoprotein (cytarabine), or less susceptible to MDR (topotecan), contributed to treatment of the metastasis. On achieving complete response, he was consolidated with supralethal-dosage carboplatin, etoposide, and cyclophosphamide, and his bone marrow rescued with autologous cord blood stem cells.
RESULTS:

Following 1-cycle systemic chemotherapy and 2-dose intraventricular chemotherapy, the CSF metastasis cleared. The right eye tumor regressed completely. The patient remains in remission 8.3 years after diagnosis and 7.8 years post-transplant.
CONCLUSION:

Intensive multimodality chemotherapy can cure CSF metastasis in retinoblastoma without incurring extreme morbidity from craniospinal radiation.




What is the purpose of the authors?

a) Avoid mutation of chromosome 13
b) Relate association with pinealoblastoma
c) Use of chemical agents
d) Discard retinopathy of prematurity


Among treatments, which is very offensive

a) Cryotherapy
b) Surgery
c) External bean radiotherapy
d) Craniospinal radiation



Which was the treatment employed after eye enucleation?

a) Gentamycin, etoposide, vincristine
b) Cefalosporine, carboplatin
c) Apoptotic drugs
d) Carboplatin, etoposide, vincristine and cyclosporine



What was the outcome after one cycle of chemotherapy?

a) The patient had an eye implant
b) The patient was in resolution
c) The patient had a relapse
d) The patient died




What happen after the patient reacted to pharmacological treatment?

a) The patient was strengthen with the treatment
b) He was also treated with radiation
c) The patient showed multidrug resistance
d) The patient had severe pain


RESP
1:C
2:D
3:D
4:B
5:A Very Happy




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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Vie Ago 19, 2011 7:09 pm
Immunosuppressive disorders and risk of anal squamous cell carcinoma: a nationwide cohort study in Denmark, 1978-2005.
Sunesen KG, Nørgaard M, Thorlacius-Ussing O, Laurberg S.
Source

Department of Colorectal Surgery P, Aarhus Hospital, Aarhus University Hospital, Aarhus, Denmark. k.sunesen@rn.dk
Abstract

Compromised immune function may increase the risk of anal squamous cell carcinoma (SCC). We examined the risk of anal SCC in patients with HIV infection and other chronic disorders associated with immunosuppression. A population-based cohort study was conducted using the Danish National Patient Registry and the Danish Cancer Registry (DCR). We identified all patients with a first-time hospital contact or procedure for HIV infection, solid organ transplantation or autoimmune disease or a first-time record of haematologic malignancy in the DCR, 1978-2005, and followed these for a subsequent anal SCC, starting follow-up 1 year after diagnosis of the index disease. Standardised incidence ratios (SIRs) were computed as the ratio of observed to expected numbers of anal SCCs, based on national age-, sex- and period-specific rates. Among 4,488 patients with HIV, we observed 21 anal SCCs with 0.3 expected (SIR: 81.1 (95% confidence interval (CI): 51.6-121.9)). Risk of anal SCC was markedly increased among 5,113 solid organ recipients (SIR: 14.4 (CI: 7.0-26.4)) and 30,165 patients with haematologic malignancies (SIR: 2.3 (CI: 1.1-4.2)) but only moderately increased among 242,114 patients with autoimmune diseases (SIR: 1.3 (CI: 1.0-1.6)). SIRs varied according to type of autoimmune disease and were high in patients with Crohn's disease (SIR: 3.1 (CI: 1.2-6.4)), psoriasis (SIR: 3.1 (CI: 1.8-5.1)), polyarteritis nodosa (SIR: 8.8 (CI: 1.5-29.0)) and Wegener's granulomatosis (SIR: 12.4 (CI: 2.1-40.Cool). In conclusion, we found HIV infection, solid organ transplantation, haematologic malignancies and a range of specific autoimmune diseases strongly associated with increased risk of anal SCC.

The purpose of our research is to consider the hazard of immune function in...

a) Polyarthritis
b) Chronic disorders
c) The United States
d) Anal squamous cell carcinoma


Which method did the authors used for SIRs?

a) Identification of patients hospitalized for the first time
b) Computarized the proportion of anal SCCs
c) Analysis of records of hematologic malignancy
d) Analysis of autoinmune disease


Which type of patients had elevated chance of anal squamous cell carcinoma?

a) Patients with an elevated incidence ratio
b) Patients with hematologic malignancies
c) Patients with solid organs
d) Patients with psoriasis



Due to the increased chance in developing anal SCC, the authors infere that

a) SCC varied according to type of autoinmune disease
b) The chances were higher in first time hospitalization patients
c) The risk was related with a number od conditions and distinguishing diseases
d) In patients with HIV


RESP
1.D
2.B
3.C
4.C



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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Vie Ago 19, 2011 8:25 pm
de donde los sacas fer?

_________________
Miembro 4º x del Club de Fans de la Dra. Koko
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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Vie Ago 19, 2011 8:31 pm
del simulador!!!
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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Vie Ago 19, 2011 11:50 pm
Dra koko puede borrar ese coment porfa!!!
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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Sáb Ago 20, 2011 12:10 am
Listo... Very Happy
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dr fer
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Re: TEXTOS EN INGLES CON PREGUNTAS!! LECTURA DE COMPRENSION :D

el Sáb Ago 20, 2011 3:46 pm
GRADIASHHHHH!! Smile
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